Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0081oc6.6 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1-splicing and mTOR/ß-catenin pathways imbalances

G-Garcia Miguel E , Fuentes-Fayos Antonio C , Gomez Jesus Perez , Jimenez-Vacas Juan M , Blanco-Acevedo Cristobal , Sanchez-Sanchez Rafael , Solivera Juan , Breunig Joshua , Gahete Manuel D , Castano Justo P , Luque Raul M

Glioblastoma (GBM; grade IV astrocytoma) is one of the most devastating endocrine-related cancer worldwide based on its locally aggressive behavior and because it cannot be cured by current therapies. Therefore, the identification of novel diagnostic and prognostic biomarkers, and especially efficient therapeutic targets is urgently needed. In this sense, defects in alternative splicing process are associated with poor survival and high aggressiveness in cancer, including GBM....
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ea0073oc13.5 | Oral Communications 13: Pituitary and Neuroendocrinology | ECE2021

Potential therapeutic role of somatostatin and cortistatin in prostate cancer

Gomez Jesus Perez , Sáez-Mart Prudencio , Jiménez-Vacas Juan M. , Herrero-Aguayo nez-Vacas> , Pedraza-Arévalo Sergio , Enrique Gómez-Gómez , León-González Antonio J. , Martínez-Fuentes Antonio J. , Castaño Antonio J. , Gahete Manuel D. , Luque Raúl M.

Somatostatin (SST), Cortistatin (CORT), Neuronostatin (NST) and their receptors [SST/CORT-receptors (sst1–5/sst5TMD4-TMD5) and NST-receptor (GPR107)] comprise a hormonal pleiotropic system involved in the regulation of multiple pathophysiological functions. Certain components of this system are dysregulated in endocrine-related cancers, including prostate cancer (PCa), wherein we have found that alterations in specific components of this regulatory system [i.e. NST-GPR10...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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